Don't ignore your symptoms

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New protein causing post-exertional malaise hints at new diagnostic tests and drugs for ME/CFS,
Flaws found by critics in the PACE Trials and Cochrane Review recommending graded exercise therapy and Cognitive behavioural therapy for ME/CFS - the Australian clinical guidelines are based on pseudoscience.
Presented and produced by Ian Woolf

Sigmund Freud 1895

WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome
Protein may be linked to exercise intolerance in ME/CFS

An exercise trial for long covid is being criticized by some patients
Ivestigating the parallels between ME/CFS and Long COVID
COVID-19 and post-infectious myalgic encephalomyelitis/chronic fatigue syndrome: a narrative review

Conversion disorder: the modern hysteria
Why did Karl Popper criticize Freud's theories?
Karl Popper: The Line Between Science and Pseudoscience
Karl Popper

Protocol for the PACE trial: A randomised controlled trial of adaptive pacing, cognitive behaviour therapy, and graded exercise as supplements to standardised specialist medical care versus standardised specialist medical care alone for patients with the chronic fatigue syndrome/myalgic encephalomyelitis or encephalopathy

A randomised trial of adaptive pacing therapy, cognitive behaviour therapy, graded exercise, and specialist medical care for chronic fatigue syndrome (PACE): statistical analysis plan (PACE trial)
Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial

Exercise therapy for chronic fatigue syndrome

Formal complaint of Cochrane Review from Dr Robert Courtney.

Pressure grows on Lancet to review “flawed” PACE trial
The Updated NICE Guidance Exposed the Serious Flaws in CBT and Graded Exercise Therapy Trials for ME/CFS
Rethinking the treatment of chronic fatigue syndrome—a reanalysis and evaluation of findings from a recent major trial of graded exercise and CBT

Controversy over exercise therapy for chronic fatigue syndrome: Key lessons for clinicians and academics
Graded exercise therapy for myalgic encephalomyelitis/chronic fatigue syndrome is not effective and unsafe. Re-analysis of a Cochrane review
Treatment Harms To Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Bad science misled millions with chronic fatigue syndrome. Here’s how we fought back
Do graded activity therapies cause harm in chronic fatigue syndrome?

Adverse outcomes in trials of graded exercise therapy for adult patients with chronic fatigue syndrome

2020 NICE reverses advice on exercise therapy for treatment of chronic fatigue syndrome in draft guidance
2021 ME exercise therapy guidance scrapped by health watchdog NICE
Chronic fatigue syndrome advice scraps exercise therapy
2020 NICE backtracks on graded exercise therapy and CBT in draft revision to CFS guidance

Graded exercise therapy does not restore the ability to work in ME/CFS – Rethinking of a Cochrane review

Death in Chronic Fatigue Syndrome (ME/CFS) – What has it Told Us? The Autopsy Files

ME study: Graded Exercise Therapy ban 'could harm' patients

ME isn’t just ‘exercise phobia’: it’s a physical illness

The Effects Of Graded Exercise Therapy And Positive Thinking On A Young Girl With ME
Five things to know about Long Covid and chronic fatigue syndrome
When the doctor doesn’t listen
Has Long COVID Always Existed?
No ‘Recovery’ in PACE Trial, New Analysis Finds
The PACE Trial Invalidates the Use of Cognitive Behavioral and Graded Exercise Therapy in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome: A Review
US Centres for Disease Control ME/CFS treatment

TRIAL BY ERROR: The Troubling Case of the PACE Chronic Fatigue Syndrome Study (second installment) 2
TRIAL BY ERROR: The Troubling Case of the PACE Chronic Fatigue Syndrome Study (final installment) 3
Why myalgic encephalomyelitis/chronic fatigue syndrome is nothing like everyday tiredness

UK NHS ME/CFS treatment guidelines

Whoops! Did a GET Study Just Explain Why It DOESN’T Work in Chronic Fatigue Syndrome (ME/CFS)?
MAYO CLINIC REMOVES GET AND CBT FROM CFS WEBPAGE
Graded exercise therapy 'should no longer be recommended for people with ME'
CDC Removes Reference to Disputed ME/CFS Therapies From Website

Graded exercise therapy for myalgic encephalomyelitis/chronic fatigue syndrome is not effective and unsafe. Re-analysis of a Cochrane review
The Cochrane correspondence
GET and CBT are ineffective or cause harm in ME-patients

Anger over exercise advice in chronic fatigue syndrome
Chronic fatigue syndrome Clinical practice guidelines for Australia — 2002

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